American Heart Associatation:
Predoctoral Fellowship; Henson David BA; University of Kentucky, Lexington KY;
Modulation of antibodies targeting apolipoprotein A -I to reduce atherosclerosis in a mouse model
TL1 Project Title: Evaluation of Nuanced Antibody Response to C-Terminal Peptide of ApoAI in Cardiovascular Disease
Patients with cardiovascular disease (CVD) possess IgG auto-antibodies targeting apolipoprotein A-I (ApoA-I), which correlates to poor CVD outcomes. Evaluation of these antibodies have focused on the IgG response to the full length unmodified protein. My project with Dr. Venditto will evaluate a much more nuanced immune response, evaluating IgG and IgM antibodies which target specific immunogenic epitopes of the ApoA-I protein with and without post-translational modification. Our eventual goal is to utilize these antibody responses to develop a risk stratification assessment tool in patients with CVD and develop novel therapeutics to prevent and treat disease progression.
The CCTS TL1 Predoctoral Training Program provides junior trainees with the skills required to develop a career in multidisciplinary clinical and translational research. The program uses a team-science approach and provides mentoring and didactic training for predoctoral students performing clinical and/or translational research in health-related fields. TL1 trainees will initially receive one year of funding, including a stipend and a $1,000 travel allowance to attend and/or present research at one conference. A second year of funding may be awarded based on performance and progress.