Kristin B Linscott

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Education
Research
Publications

Position(s):

MD/PhD Student

Affiliation(s):

Molecular & Cellular Biochemistry

MD/PhD Program

Interests / Specialties:

Bio / Education:

Education:
B.A., Biology, Agnes Scott College (2010)
B.A., Religious Studies and Social Justice, Agnes Scott College (2010)
PhD, Molecular and Cellular Biochemistry, University of Kentucky (2017)
M.D. Candidate, University of Kentucky College of Medicine (exp. 2019)

Mentor:

Dr. Joseph Chappell

Research Description:

As a graduate student in biochemistry, Kristin's work involved mapping interaction domains for enzymes in the sterol biosynthetic pathway that are unique to each kingdom of life, and so can be used to develop novel therapeutics for treating fungal and protozoan infections in humans.

PubMed Publications:

Jiang, Z.; Kempinski, C.; Kumar, S.; Kinison, S.; Linscott, K.; Nybo, E.; Janze, S.; Wood, C.; Chappell, J. "Agronomic and chemical performance of field-grown tobacco engineered for triterpene and methylated triterpene metabolism." Plant biotechnology journal 16, 6 (2018): 1110-1124. [PubMed Link] | [ Full text ]
Linscott, KB ; Niehaus, TD ; Zhuang, X.; Bell, SA ; Chappell, J. "Mapping a kingdom-specific functional domain of squalene synthase." Biochimica et biophysica acta 1861, 9 Pt A (2016): 1049-1057. [PubMed Link] | [ Full text ]
Kumar, S.; Kempinski, C.; Zhuang, X.; Norris, A.; Mafu, S.; Zi, J.; Bell, SA ; Nybo, SE ; Kinison, SE ; Jiang, Z.; Goklany, S.; Linscott, KB ; Chen, X.; Jia, Q.; Brown, SD ; Bowman, JL ; Babbitt, PC ; Peters, RJ ; Chen, F.; Chappell, J. "Molecular Diversity of Terpene Synthases in the Liverwort Marchantia polymorpha." The Plant cell 28, 10 (2016): 2632-2650. [PubMed Link] | [ Full text ]
Dolan Thomas, J.; Hatcher, CP ; Satterfield, DA ; Theodore, MJ ; Bach, MC ; Linscott, KB ; Zhao, X.; Wang, X.; Mair, R.; Schmink, S.; Arnold, KE ; Stephens, DS ; Harrison, LH ; Hollick, RA ; Andrade, AL ; Lamaro-Cardoso, J.; Lemos, AP ; Gritzfeld, J.; Gordon, S.; Soysal, A.; Bakir, M.; Sharma, D.; Jain, S.; Satola, SW ; Messonnier, NE ; Mayer, LW "sodC-based real-time PCR for detection of Neisseria meningitidis." PloS one 6, 5 (2011): e19361. [PubMed Link] | [ Full text ]
Robic, S.; Linscott, KB ; Aseem, M.; Humphreys, EA ; McCartha, SR "Bile acids as modulators of enzyme activity and stability." The protein journal 30, 8 (2011): 539-45. [PubMed Link] | [ Full text ]