Chris Brown
Connect
859-323-4860christopher.a.brown@uky.edu
Positions
- MD/PhD Student
College Unit(s)
Biography and Education
Education
BA Washington University, 2011 PhD University of Kentucky, 2017
Summary:
Current Year: M4Research
I am interested in neuroimaging markers of cognitive decline in aging and Alzheimer's disease. My main interest is looking at white matter changes using an MRI technique called DTI. White matter is responsible for electrochemical signaling between brain regions, and breakdown occurs both in aging and disease. I am particularly interested in exploring how this decline in white matter interacts with Alzheimer's disease pathology to alter brain function leading to cognitive decline.
Selected Publications
Brown, CA ;Jiang, Y.;Smith, CD ;Gold, BT "Age and Alzheimer's pathology disrupt default mode network functioning via alterations in white matter microstructure but not hyperintensities." Cortex; a journal devoted to the study of the nervous system and behavior 104, (2018): 58-74. Available from: http://dx.doi.org/10.1016/j.cortex.2018.04.006 PMCID: 29758374 Brown CA, Johnson NF, Andeson-Mooney AJ, Jicha GA, Shaw LM, Trojanowski JQ, Van Eldik LJ, Schmitt FA, Smith CD, Gold BT. Development, validation, and application of a new fornix template for studies of aging and preclinical Alzheimer's disease. NeuroImage: Clinical. 2017. Available from: http://dx.doi.org/10.1016/j.nicl.2016.11.024 PMCID: 5137184 Brown CA, Hakun JG, Zhu Z, Johnson NF, Gold BT. White matter microstructure contributes to age-related declines in task-induced deactivation of the default mode network. Frontiers in Aging Neuroscience. 2015. Available from: http://www.frontiersin.org/Journal/Abstract.aspx?s=18&name=aging_neuros… PMCID: 4598480 Brown CA, Karimi MK, Tian L, Flores H, Su Y, Tabbal SD, Loftin SK, Moerlein SM, Perlmutter JS. Validation of midbrain positron emission tomography measures for nigrostriatal neurons in macaques. Ann Neurol. 2013 Oct;74(4):602–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23686841 PMCID: 23686841 Brown CA, Campbell MC, Karimi M, Tabbal SD, Loftin SK, Tian LL, Moerlein SM, Perlmutter JS. Dopamine pathway loss in nucleus accumbens and ventral tegmental area predicts apathetic behavior in MPTP-lesioned monkeys. Exp Neurol. 2012 Jul;236(1):190–7. Available from: http://www.sciencedirect.com/science/article/pii/S0014488612001975 PMCID: 22579525