BS in Chemistry and Minor in Math, Roanoke College, 2013
I am interested in understanding how metabolic changes impact the progression and therapy of triple negative breast cancer, a very aggressive disease for which there are few treatment options. My current work is focused on AMP-activated protein kinase (AMPK), a key metabolic regulator that is a context-dependent tumor suppressor and tumor promoter. I am trying to determine the role of this protein under normal metabolic conditions as well as under metabolically-stressful conditions. I have also used a novel compound synthesized at UK to stimulate AMPK's tumor suppressive properties in TNBC.
Johnson J, Rychahou P, Sviripa VM, Weiss HL, Liu C, Watt DS, et al. (2019) Induction of AMPK activation by N,N’-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers. PLoS ONE 14(3): e0209392.