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Susan S. Smyth, M.D., Ph.D.
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susansmyth@uky.edu
859-323-2274
859-218-0121
741 South Limestone Street, Biomedical/Biological Sciences Research Building, Rm: B347, Lexington, KY 40536-0509
https://www.facebook.com/GillHeartInstitute/
Position(s): 
Jeff Gill Professor of Cardiology
Chief | Division of Cardiovascular Medicine
Director | Gill Heart Institute
Affiliation(s): 
Internal Medicine
Physiology
MD/PhD Program
Cardiovascular Research Center
CV Imaging Research Team
Other Affiliation(s): 
Lexington VAMC
CVRC - Core Faculty
Internal Medicine - Cardiology
Physiology - Joint Faculty
pharmns-Joint Faculty
Interests / Specialties: 
Cardiovascular Medicine
Thrombosis & Inflammation
Bio / Education: 
MD, University of North Carolina, Chapel Hill
PhD, Pharmacology, University of North Carolina, Chapel Hill
 

Dr. Susan Smyth is a physician scientist who combines clinical practice in cardiology with NIH- , VA-, and industry-funded research focused on the interplay between inflammation and thrombosis in vascular biology. Her training and expertise center around the contribution of extracellular mediators and blood and vascular cell-surface signaling receptors. Her team applies genetic and pharmacologic strategies in animal models of cardiovascular disease, in order to define cellular and molecular pathways, and then tests those pathways in clinical studies in humans. Her clinical interests are in arterial and venous thrombosis, and she leads an enterprise-wide effort in thrombosis prevention and management.  She has authored more than 150 publications and contributed to over a dozen textbooks. 

Smyth received her A.B. in Biology, summa cum laude, from Mount Holyoke College (South Hadley, Massachusetts), and graduated from the MD/PhD Program at the University of North Carolina (Chapel Hill, NC). As a graduate student, she studied activation of the platelet integrin αIIbβ3.  After completing training in Internal Medicine, she performed cardiology subspecialty fellowship training at the Mount Sinai School of Medicine (New York, New York) and at the University of North Carolina.  While a fellow at Mount Sinai, Smyth established animal models to study platelet and other cell-surface receptors in thrombosis and vascular biology.  During this time, she developed an interest in understanding the interesection of thrombosis and inflammation based on observations of platelet – leukocyte interactions in models of vascular disease. Smyth joined the faculty of the University of North Carolina as an Assistant Professor of Medicine and Physiology in 2001. During her tenure at UNC, her group expanded their research to understanding of the role of bioactive, extracellular lysolipids in vascular biology.  She joined the faculty of at the University of Kentucky (Lexington, Kentucky) in 2006 and currently holds appointments in the Departments of Internal Medicine, Pharmacology, Physiology, and Behavioral Sciences.  Smyth is part of a research team whose work spans molecular, preclinical and clinical models, with an aim to connect discovery science to prevent cardiovascular disease and promote health.

To learn more about Dr. Smyth, click here

For Dr. Smyth's clinical page, click here 

To read more about the research, click here

ATX-LPA-LPP3 nexus

 

Select Honors and Positions

2000      Faculty Scholar Award, American Society of Hematology
2003      American Heart Association Young Investigator Prize in Thrombosis, finalist
2005-     Editorial Panel: Clinical Science
2007-     Editorial Board, Arteriosclerosis, Thrombosis and Vascular Biology
2008      Special Recognition Award in Thrombosis, ATVB Council, American Heart Association
2009      Stewart-Nierwiarowski Award for Women in Vascular Biology
2009      Member, American Society of Clinical Investigation
2010     Associate Editor, Journal Thrombosis and Thrombolysis (section editor Fellow’s Forum)
2012      Consulting Editor, Journal of Clinical Investigation
2013      Jeffrey M. Hoeg Arteriosclerosis Award for Basic Science and Clinical Research
2013      Member, Association of University Cardiologists
2016      Board of Governors, American College of Cardiology
2016      PERT Consortium™, Founding Board Member
2018      Alumni Award, University of Kentucky
2019      Association of University Cardiologists, President-Elect
2019      Chair, FASEB conference on Lysophospholipids in Health and Disease
2019      Senior Clinical Scientist Award, Department of Veterans Affairs
PubMed Publications: 
  • Mao, G.; Smyth, SS ; Morris, AJ "Regulation of PLPP3 gene expression by NF-κB family transcription factors." The Journal of biological chemistry 294, 38 (2019): 14009-14019. [PubMed Link] | [ Full text ]
  • Ogunbayo, GO ; Ha, LD ; Ahmad, Q.; Misumida, N.; Okwechime, R ; Elbadawi, A.; Abdel-Latif, A.; Elayi, CS ; Smyth, S.; Boccara, F ; Messerli, AW "Treatment Bias in Management of HIV Patients Admitted for Acute Myocardial Infarction: Does It Still Exist?" Journal of general internal medicine (2019): [PubMed Link] | [ Full text ]
  • Mueller, PA ; Yang, L.; Ubele, M ; Mao, G.; Brandon, J.; Vandra, J ; Nichols, TC ; Escalante-Alcalde, D.; Morris, AJ ; Smyth, SS "Coronary Artery Disease Risk-Associated <i>Plpp3</i> Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis." Arteriosclerosis, thrombosis, and vascular biology 39, 11 (2019): 2261-2272. [PubMed Link] | [ Full text ]
  • Kraemer, MP ; Mao, G.; Hammill, C ; Yan, B.; Li, Y.; Onono, F.; Smyth, SS ; Morris, AJ "Effects of diet and hyperlipidemia on levels and distribution of circulating lysophosphatidic acid." Journal of lipid research 60, 11 (2019): 1818-1828. [PubMed Link] | [ Full text ]
  • Smyth, SS ; Natarajan, V.; McMullen, CA "The 2019 FASEB Science Research Conference on Lysophospholipid and Related Mediators: From Bench to Clinic, July 28 to August 2, 2019, Lisbon, Portugal." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33, 11 (2019): 11622-11624. [PubMed Link] | [ Full text ]
  • Yang, L.; Kraemer, M ; Fang, XF ; Angel, PM ; Drake, RR ; Morris, AJ ; Smyth, SS "LPA receptor 4 deficiency attenuates experimental atherosclerosis." Journal of lipid research 60, 5 (2019): 972-980. [PubMed Link] | [ Full text ]
  • Murph, MM ; Liu, S.; Jia, W.; Nguyen, H.; MacFarlane, MA ; Smyth, SS ; Kuppa, SS ; Dobbin, KK "Diet-regulated behavior: FVB/N mice fed a lean diet exhibit increased nocturnal bouts of aggression between littermates." Laboratory animals (2019): 23677219834582. [PubMed Link] | [ Full text ]
  • Wu, C.; Lu, W.; Zhang, Y.; Zhang, G.; Shi, X.; Hisada, Y ; Grover, SP ; Zhang, X.; Li, L.; Xiang, B.; Shi, J.; Li, XA ; Daugherty, A.; Smyth, SS ; Kirchhofer, D.; Shiroishi, T ; Shao, F.; Mackman, N.; Wei, Y.; Li, Z. "Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis." Immunity 50, 6 (2019): 1401-1411.e4. [PubMed Link] | [ Full text ]
  • Ogunbayo, GO ; Pecha, R ; Misumida, N.; Goodwin, E.; Ayoub, K ; Hillerson, D ; Elbadawi, A.; Abdel-Latif, A.; Elayi, CS ; Messerli, AW ; Smyth, SS "Outcomes of fibrinolytic therapy for patients with metastatic cancer and acute pulmonary embolism." Pulmonary pharmacology & therapeutics 56, (2019): 104-107. [PubMed Link] | [ Full text ]
  • Hillerson, D ; Ogunbayo, GO ; Salih, M.; Misumida, N.; Abdel-Latif, A.; Smyth, SS ; Messerli, AW "Outcomes and Characteristics of Myocardial Infarction in Patients With Cirrhosis." The Journal of invasive cardiology 31, 7 (2019): E162-E169. [PubMed Link] | [ Full text ]
  • Shrout, T.; Sexton, T.; Vsevolozhskaya, O.; Guglin, M.; Shafii, A ; Smyth, S. "Early signatures of bleeding and mortality in patients on left ventricular assist device support: novel methods for personalized risk-stratification." Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 24, 5 (2019): 448-456. [PubMed Link] | [ Full text ]
  • Xenos, ES ; Davis, GA ; He, Q.; Green, A.; Smyth, SS "The implementation of a pulmonary embolism response team in the management of intermediate- or high-risk pulmonary embolism." Journal of vascular surgery. Venous and lymphatic disorders 7, 4 (2019): 493-500. [PubMed Link] | [ Full text ]
  • Ogunbayo, GO ; Pecha, R ; Misumida, N.; Hillerson, D ; Elbadawi, A.; Abdel-Latif, A.; Elayi, CS ; Messerli, AW ; Smyth, SS "Relation of CHA<sub>2</sub>DS<sub>2</sub>VASC Score With Hemorrhagic Stroke and Mortality in Patients Undergoing Fibrinolytic Therapy for ST Elevation Myocardial Infarction." The American journal of cardiology 123, 2 (2019): 212-217. [PubMed Link] | [ Full text ]
  • Sexton, T.; Alkhasova, M ; Beer, M.; Lynch, D.; Smyth, S. "Changes in thromboinflammatory profiles across the generations of transcatheter aortic heart valves." Journal of thrombosis and thrombolysis 47, 2 (2019): 174-178. [PubMed Link] | [ Full text ]
  • Wayne, NB ; Davis, GA ; Macaulay, TE ; Beavers, CJ ; Messerli, AW ; Dugan, A.; Smyth, SS "Reduced dose thrombolysis with ultrasound-facilitated catheter-directed administration for acute pulmonary embolism reduces length of stay." Journal of thrombosis and thrombolysis (2019): [PubMed Link] | [ Full text ]
  • Ogunbayo, GO ; Messerli, AW ; Ha, LD ; Elbadawi, A.; Olorunfemi, O.; Darrat, Y.; Guglin, M.; Okwechime, R ; Akanya, D ; Abdel-Latif, A.; Smyth, SS ; Elayi, CS "Trends in the Incidence and In-Hospital Outcomes of Patients With Atrial Fibrillation Complicated by Non-ST-Segment Elevation Myocardial Infarction." Angiology 70, 4 (2019): 317-324. [PubMed Link] | [ Full text ]
  • Ogunbayo, GO ; Shrout, TA ; Misumida, N.; Abdel-Latif, A.; Smyth, SS ; Messerli, AW ; Ziada, KM "Trends, Management Patterns, and Predictors of Leaving Against Medical Advice among Patients with Documented Noncompliance Admitted for Acute Myocardial Infarction." Journal of general internal medicine 34, 4 (2019): 486-488. [PubMed Link] | [ Full text ]
  • Brandon, JA ; Kraemer, M ; Vandra, J ; Halder, S.; Ubele, M ; Morris, AJ ; Smyth, SS "Adipose-derived autotaxin regulates inflammation and steatosis associated with diet-induced obesity." PloS one 14, 2 (2019): e0208099. [PubMed Link] | [ Full text ]
  • Kuppa, SS ; Jia, W.; Liu, S.; Nguyen, H.; Smyth, SS ; Mills, GB ; Dobbin, KK ; Hardman, WJ ; Murph, MM "Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p." Cancer letters 432, (2018): 84-92. [PubMed Link] | [ Full text ]
  • Bhalla, V ; Abdel-Latif, A.; Bhalla, M ; Ziada, K.; Williams, MV ; Smyth, SS "Meta-Analysis Comparing the Efficacy, Safety, and Cost-Benefit of Direct Acting Oral Anticoagulants Versus Enoxaparin Thromboprophylaxis to Prevent Venous Thromboembolism Among Hospitalized Patients." The American journal of cardiology 122, 7 (2018): 1236-1243. [PubMed Link] | [ Full text ]
  • George, B.; Davis, G.; Guglin, M.; Smyth, S. "Reply to: A protocolized approach to veno-arterial extracorporeal membrane oxygenation for massive pulmonary embolism." Resuscitation 126, (2018): e13. [PubMed Link] | [ Full text ]
  • George, B.; Parazino, M.; Omar, HR ; Davis, G.; Guglin, M.; Gurley, J.; Smyth, S. "A retrospective comparison of survivors and non-survivors of massive pulmonary embolism receiving veno-arterial extracorporeal membrane oxygenation support." Resuscitation 122, (2018): 1-5. [PubMed Link] | [ Full text ]
  • Becker, RC ; Sexton, T.; Smyth, SS "Translational Implications of Platelets as Vascular First Responders." Circulation research 122, 3 (2018): 506-522. [PubMed Link] | [ Full text ]
  • Ogunbayo, GO ; Misumida, N.; Ayoub, K ; Hailemariam, Y ; Hillerson, D ; Elbadawi, A.; Abdel-Latif, A.; Smyth, S.; Ziada, K.; Messerli, AW "Temporal trends, characteristics and outcomes of fibrinolytic therapy for ST-elevation myocardial infarction among patients 80 years or older." Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 92, 7 (2018): E425-E432. [PubMed Link] | [ Full text ]
  • Sexton, TR ; Zhang, G.; Macaulay, TE ; Callahan, LA ; Charnigo, R.; Vsevolozhskaya, OA ; Li, Z.; Smyth, S. "Ticagrelor Reduces Thromboinflammatory Markers in Patients With Pneumonia." JACC. Basic to translational science 3, 4 (2018): 435-449. [PubMed Link] | [ Full text ]
  • Ogunbayo, GO ; Bidwell, K.; Misumida, N.; Ha, LD ; Abdel-Latif, A.; Elayi, CS ; Smyth, S.; Messerli, AW "Sex differences in the contemporary management of HIV patients admitted for acute myocardial infarction." Clinical cardiology 41, 4 (2018): 488-493. [PubMed Link] | [ Full text ]
  • Kraemer, MP ; Halder, S.; Smyth, SS ; Morris, AJ "Measurement of Lysophosphatidic Acid and Sphingosine-1-Phosphate by Liquid Chromatography-Coupled Electrospray Ionization Tandem Mass Spectrometry." Methods in molecular biology (Clifton, N.J.) 1697, (2018): 31-42. [PubMed Link] | [ Full text ]
  • Federico, L.; Yang, L.; Brandon, J.; Panchatcharam, M.; Ren, H.; Mueller, P.; Sunkara, M.; Escalante-Alcalde, D.; Morris, AJ ; Smyth, SS "Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice." PloS one 13, 6 (2018): e0198063. [PubMed Link] | [ Full text ]
  • Butt, MU ; Buzsaki, LA ; Smyth, SS ; Elayi, SC "Deep Vein Thrombosis Complicated by Spontaneous Iliopsoas Hematoma in Patient with Septic Shock." The American journal of case reports 18, (2017): 1148-1152. [PubMed Link] | [ Full text ]
  • Ogunbayo, GO ; Misumida, N.; Olorunfemi, O.; Elbadawi, A.; Saheed, D.; Messerli, A.; Elayi, CS ; Smyth, SS "Comparison of Outcomes in Patients Having Acute Myocardial Infarction With Versus Without Sickle-Cell Anemia." The American journal of cardiology 120, 10 (2017): 1768-1771. [PubMed Link] | [ Full text ]
  • Smetana, KS ; Dunne, J.; Parrott, K.; Davis, GA ; Collier, ACS ; Covell, M.; Smyth, S. "Oral factor Xa inhibitors for the treatment of left ventricular thrombus: a case series." Journal of thrombosis and thrombolysis 44, 4 (2017): 519-524. [PubMed Link] | [ Full text ]
  • Dong, A.; Mueller, P.; Yang, F.; Yang, L.; Morris, A.; Smyth, SS "Direct thrombin inhibition with dabigatran attenuates pressure overload-induced cardiac fibrosis and dysfunction in mice." Thrombosis research 159, (2017): 58-64. [PubMed Link] | [ Full text ]
  • Ogunbayo, GO ; Charnigo, R.; Darrat, Y.; Morales, G.; Kotter, J.; Olorunfemi, O.; Elbadawi, A.; Sorrell, VL ; Smyth, SS ; Elayi, CS "Incidence, predictors, and outcomes associated with pneumothorax during cardiac electronic device implantation: A 16-year review in over 3.7 million patients." Heart rhythm 14, 12 (2017): 1764-1770. [PubMed Link] | [ Full text ]
  • Brewster, J.; Sexton, T.; Dhaliwal, G.; Charnigo, R.; Morales, G.; Parrott, K.; Darrat, Y.; Gurley, J.; Smyth, S.; Elayi, CS "Acute Effects of Implantable Cardioverter-Defibrillator Shocks on Biomarkers of Myocardial Injury, Apoptosis, Heart Failure, and Systemic Inflammation." Pacing and clinical electrophysiology : PACE 40, 4 (2017): 344-352. [PubMed Link] | [ Full text ]
  • Kotter, J.; Lolay, G.; Charnigo, R.; Leung, S.; McKibbin, C.; Sousa, M.; Jimenez, L.; Gurley, J.; Biase, LD ; Natale, A.; Smyth, S.; Darrat, Y.; Morales, G.; Elayi, CS "Predictors, Morbidity, and Costs Associated with Pneumothorax during Electronic Cardiac Device Implantation." Pacing and clinical electrophysiology : PACE 39, 9 (2016): 985-91. [PubMed Link] | [ Full text ]
  • Morris, AJ ; Smyth, SS "Regulation of Lysophosphatidic Acid Metabolism and Signaling by Lipoproteins." Arteriosclerosis, thrombosis, and vascular biology 36, 10 (2016): 2029-30. [PubMed Link] | [ Full text ]
  • Sexton, TR ; Wallace, EL ; Chen, A.; Charnigo, RJ ; Reda, HK ; Ziada, KM ; Gurley, JC ; Smyth, SS "Thromboinflammatory response and predictors of outcomes in patients undergoing transcatheter aortic valve replacement." Journal of thrombosis and thrombolysis 41, 3 (2016): 384-93. [PubMed Link] | [ Full text ]
  • Sexton, T.; Wallace, EL ; Smyth, SS "Anti-Thrombotic Effects of Statins in Acute Coronary Syndromes: At the Intersection of Thrombosis, Inflammation, and Platelet-Leukocyte Interactions." Current cardiology reviews 12, 4 (2016): 324-329. [PubMed Link] | [ Full text ]

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